Risk Factors for Hemorrhagic Transformation after Acute Cerebral Infarction

Objective To explore the relevant risk factors for hemorrhagic transformation(HT) after acute cerebral infarction.Methods A total of 818 patients with acute cerebral infarction who were treated in our hospital from June 2011 to June 2013,were selected as study subjects,observation group included 135(16.5%) HT cases,control group included 683(83.5%) non- HT cases.Clinical indicators were analyzed retrospectively,and were compared between two groups.Univariate t- test,chi- square test and non- conditional Logistic regression analysis were performed to detect the relevant risk factors for HT after acute cerebral infarction.Results Prevalence of diabetes mellitus,coronary heart disease,atrial fibrillation,hyperglycemia,proteinuria,massive cerebral infarction and fasting glucose level in observation group were significantly higher than those in control group(P 0.05),but prevalence of drinking in observation group was significantly lower than that in control group(P 0.05).The results of multivariate Logistic regression analysis revealed that diabetes mellitus 〔OR = 1.787,95% CI(1.186,2.691),P =0.005〕,atrial fibrillation 〔OR =1.802,95% CI(1.112,9.919),P =0.017〕,and massive cerebral infarction 〔OR = 6.477,95% CI(4.198,9.991),P = 0.000〕were independent risk factors for HT after acute cerebral infarction.Conclusion Diabetes mellitus,atrial fibrillation and massive cerebral infarction are the independent risk factors for HT after acute cerebral infarction.