The clinical features of hemorrhagic transformation after cerebral infarction and the analysis of risk factors

Objective To summarize the clinical features of hemorrhagic transformation( HT) after cerebral infarction and analyze the related risk factors,in order to guide the diagnosis,treatment and prevention of the disease. Methods The clinical data of 160 patients with cerebral infarction were collected. The patients were treated in our hospital from September 2010 to March 2013. The patients with HT or without HT were assigned to HT group( n = 42) and NHT group( n = 118) respectively. The following data were obtained including basic information of the patients( age,sex,medical history),clinical manifestation,infarction area,bleeding site,thrombolysis and administration of anticoagulation and antiplatelet aggregation drugs before and after the onset of the disease and urine protein. The risk factors associated with HT were analyzed. Results Clinical features of patients in HT group were hemiplegia( 76. 1%),aphasia( 50. 0%),disturbance of consciousness( 26. 2%),and headache and dizziness( 21. 4%). Risk factors for HT after cerebral infarction included hypercholesterolemia,large area cerebral infarction,history of atrial fibrillation and urine protein positive. However,there were no statistically significant differences in age,smoking and alcohol abuse between HT and NHT group( P 0. 05). Conclusion Hemorrhagic transformation after cerebral infarction may be the result of joint action of many factors; large area cerebral infarction,positive urine protein,hypercholesterolemia,and a history of atrial fibrillation are major risk factors for HT.