Clinical application of antinuclear antibodies in autoimmune diseases

Objective To discuss the clinical significance of anti-nuclear antibody(ANA) in treatment of autoimmune diseases(AID).Methods 2 055 patients up to the diagnosis standards were selected.The ANA in serum of patients was measured by indirect immunofluorescence.The positive rate,karyotype and titer of ANA were analyzed in the above AID.Results The titer of ANA in AID patients group was 1:80 while 1:160 in the control group.ANA positive rate of AID patients group was 80%,and its difference with control group had statistical significance (P0.01).The highest rate was in systemic lupus erythematosus(SLE) patients.Fluorescence patterns of ANA statistics were spot-type based for SLE,drying syndrome,rheumatoid arthritis patients.The homogenous and the nuclear core spots were mainly for autoimmune hepatitis patients.Conclusion The positive rate and titer of ANA are different among various AID patients. More attention should be paid to the titer value of ANA in the ANA test.Because more and more types of ANA fluorescence patterns are found,and different models represent different fluorescent target antigen.In particular,some special fluorescent models play an important role in the diagnosis of AID.