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2009•Laboratory Medicine and ClinicRequires access

Comparison of two methods in detecting HBsAg

LI Jie-r

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Abstract

Objective To compare gold immunochromatography assay(GICA)with enzyme linked immunosorbent assay(ELISA)in detecting HBsAg.Methods GICA and ELISA were used to detect HBsAg in serum from 4 086 individuals aged from 18 to 65 years.Results A total of 327 samples(8.0%)were HBsAg positive when detected by GICA,while 391 cases(9.6%)showed positive when detected by ELISA;the positive coincidence rate was 98.43%.Conclusion Although GICA is simpler and faster than ELISA,and has a good specificity,its sensibility is still dissatisfactory.By comparison,ELISA is more suitable for serum HBsAg detection in hospitals and blood centres.

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What this paper is about

Objective To compare gold immunochromatography assay(GICA)with enzyme linked immunosorbent assay(ELISA)in detecting HBsAg.Methods GICA and ELISA were used to detect HBsAg in serum from 4 086 individuals aged from 18 to 65 years.Results A total of 327 samples(8.0%)were HBsAg positive when detected by GICA,while 391 cases(9.6%)showed positive when detected by ELISA;the positive coincidence rate was 98.43%.Conclusion Although GICA is simpler and faster than ELISA,and has a good specificity,its sensibility is still dissatisfactory.By comparison,ELISA is more suitable for serum HBsAg detection in hospitals and blood centres.

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Available abstract

Objective To compare gold immunochromatography assay(GICA)with enzyme linked immunosorbent assay(ELISA)in detecting HBsAg.Methods GICA and ELISA were used to detect HBsAg in serum from 4 086 individuals aged from 18 to 65 years.Results A total of 327 samples(8.0%)were HBsAg positive when detected by GICA,while 391 cases(9.6%)showed positive when detected by ELISA;the positive coincidence rate was 98.43%.Conclusion Although GICA is simpler and faster than ELISA,and has a good specificity,its sensibility is still dissatisfactory.By comparison,ELISA is more suitable for serum HBsAg detection in hospitals and blood centres.

Key concepts: HBsAg, Medicine, Gold standard (test), Virology, Internal medicine, Hepatitis B virus, Virus

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