2009•PubMedRequires access

[Expression of thymic stromal lymphopoietin in nasal mucosa of a mouse model with allergic rhinitis].

Meili Xu, Yongqing Guo

Abstract

OBJECTIVE: To investigate the expression of thymic stromal lymphopoietin (TSLP) in the nasal mucosa of mouse with allergic rhinitis. METHOD: Twenty wide type BALB/c mouse were divided into 2 groups randomly. Two groups were included, allergic rhinitis group (group A) and control group (group B). The mouse model of allergic rhinitis was established by ovalbumin (OVA) sensitization and challenge. The expressions of TSLP in the nasal mucosa was determined by realtime quantitative PCR and immunohistochemical method. RESULT: The expression of TSLP in the nasal mucosa of group A was significantly higher than that in group B (P<0.01). CONCLUSION: TSLP plays a role in the mouse model of allergic rhinitis.

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Key concepts: Thymic stromal lymphopoietin, Mucous membrane of nose, Ovalbumin, Immunology, Immunohistochemistry, Medicine, Sensitization, Immune system