Observation on curative effect of different doses of s-Adenosylmethionine on cholestatic hepatitis

OBJECTIVE To discuss the curative effect and safety of different doses of s-Adenosylmethionine on cholestatic hepatitis. METHODS 84 cases of patients of cholestatic hepatitis were divided into 2 groups according to different therapeutic doses of s-Adenosylmethionine( SAMe). On the basis of regular treatment,group A( 43 cases) received intravenous infusion of SAMe2000mg with one time every day,and the course of treatment lasts four weeks; Group B( 41 cases) receive intravenous infusion of SAMe1000mg with one time every day,and the course of treatment lasts four weeks also. Then the clinical symptoms,changes in liver function and adverse reactions were observe. RESULTS The liver function of these two groups of patients improved significantly( P 0. 05). The total effective rate of group A was 81. 39%,largely higher than that of group B,which was 60. 97%( P 0. 05). In the period of two and four weeks,the improvements of TBil and GGT of group A were better than these of group B( P 0. 01). There were no obvious adverse reactions in both group A and group B. CONCLUSION S-Adenosylmethionine( SAMe) is a safe and effective drug for the treatment of cholestatic hepatitis. The larger dose,the better effect. S-Adenosylmethionine( SAMe) is effective and safe and can be used in clinic treatment.