TCM syndrome development research of diabetic nephropathy in different stage

Objective: Targeted patients with early and clinical stage diabetic nephropathy(DN) to study TCM syndrome development of diabetic nephropathy in different stage.Methods: Collected TCM syndrome data of DN in early and clinical stages for syndrome differentiation and to refine the syndrome factors.And then the syndromes and syndrome factors were analyzed statistically.Results: As the disease evolved from the early stage to the clinical stage,the symptoms for internal heat induced byYin deficiency and heat hurt Qi and Yin were decreased,while the symptoms and syndrome factors for Yang deficiency were increased.The syndrome of dampness and turbid in early stage was more than the clinical stage of DN.Conclusion: From the early stage to the clinical stage,the pathogenesis of DN is from deficiency of both Qi and Yin to deficiency of both Yin and Yang,blood stasis is thoughout the whole stages and has worsening trend.The syndrome factor dampness and turbid in early stage was more opparent than the clinical stage of DN,which was always the key pathological factors.