Clinical efficacy of continuous lumbar cisterna drainage combined with intrathecal injection of vancomycin in treatment of intracranial infections after craniocerebral operation

OBJECTIVE To explore the effect of continuous lumbar cisterna drainage combined with intrathecal injection of vancomycin on the treatment of intracranial infections after craniocerebral operation so as to provide basis for the clinical diagnosis and treatment.METHODS A total of 128 patients with intracranial infections,who underwent the craniocerebral operation,were randomly divided into the treatment group and the control group,all the cases were given the intravenous and intracranial infection of vancomycin,and the treatment group was treated with continuous lumbar cisterna drainage combined additionally.The clinical effect,change of intracranial pressure and infection control were compared and analyzed between two groups.RESULTS The total effective rate in the treatment group(93.5%) was significantly better than that in the control group(77.4%) the difference was staticany significant(P0.05).After the treatment,the intracranial pressure in the treatment group(120.7±19.3) mmHg was significantly lower than that in the control group(175.3±24.8) mmHg,the difference was statistically significant(P0.05).After the treatment,the contents of the leukocyte and protein were significantly reduced,but the content of glucose was remarkably increased(P0.05).There were significant difference in the contents of the leukocyte,protein or glucose after the treatment between the observation group and the control group was statistically significant(P0.05).CONCLUSION The continuous lumbar cisterna drainage combined with intrathecal injection of vancomycin is safe and effective in treatment of the intracranial infections after craniocerebral operation and can significantly improve the symptoms of infections and regulate the intracranial pressure.