Antihypertensive effects of amlodipine besylate and losartan in elderly patients with isolated systolic hypertension evaluated by ambulatory blood pressure monitoring

OBJECTIVE To evaluate the antihypertensive effects and the trough to peak(T/P) ratios of amlodipine besylate and losartan in elderly patients with isolated systolic hypertension by ambulatory blood pressure monitoring.METHODS 60 elderly patients with isolated systolic hypertension were divided into two groups randomly,30 patients were treated with amlodipine besylate and another 30 patients were treated with losartan for 8 weeks.Ambulatory blood pressure,clinical blood pressure(CBP),heart rate and biochemical indicators were examined before and after the treatment.RESULTS After 8wk treatment,CBP,mean systolic blood pressure(SBP) of 24 h,daytime and night,load of SBP were significantly reduced(P0.05),while no significant difference was found in heart rate.The total effective rate of the two groups were 90% and 93% respectively.There was no significant difference in depressurizated amplitude in two groups(P0.05).The T/P ratios were higher than 50% and the adverse effects were mild in two groups.CONCLUSION Both of amlodipine besylate and losartan can reduce the SBP in elderly patients stably,effectively and safely,and has little adverse effects,therefore,they can be first-line antihypertensive agents.