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2007•Chinese Journal of Hospital PharmacyRequires access

Expression of heat shock protein 70 in myocardial tissue in rats with endotoxemia and effects of pentoxifylline

Wei Zhu

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Abstract

OBJECTIVE To study the expression of HSP70 in myocardial tissue in rats with endotoxemia and the effects of pentoxifylline.METHODS Set the models of rats with acute endotoxemia by the method of injecting LPS directly. Wistar rats were randomly divided into 3 groups,sham operated control ,LPS and PTX . The immunohistochemistry and western blotting were both used to assess the expression of HSP70 in the myocardial tissues.RESULTS The levels of HSP70 in the myocardial tissues in L group are higher than those in sham operated control group (P0.01) (immunohistochemistry and Western blotting). After PTX treatment, the levels of HSP70 in the myocardial tissues in P group are higher than those in L group (P0.01) (immunohistochemistry and western blotting).CONCLUSION The expression of HSP70 in myocardial tissues elevated in rats with endotoxemia and PTX can eliminate the myocardial injury and protect the myocardial tissues by further elevating the expression of HSP70.

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OBJECTIVE To study the expression of HSP70 in myocardial tissue in rats with endotoxemia and the effects of pentoxifylline.METHODS Set the models of rats with acute endotoxemia by the method of injecting LPS directly. Wistar rats were randomly divided into 3 groups,sham operated control ,LPS and PTX . The immunohistochemistry and western blotting were both used to assess the expression of HSP70 in the myocardial tissues.RESULTS The levels of HSP70 in the myocardial tissues in L group are higher than those in sham operated control group (P0.01) (immunohistochemistry and Western blotting). After PTX treatment, the levels of HSP70 in the myocardial tissues in P group are higher than those in L group (P0.01) (immunohistochemistry and western blotting).CONCLUSION The expression of HSP70 in myocardial tissues elevated in rats with endotoxemia and PTX can eliminate the myocardial injury and protect the myocardial tissues by further elevating the expression of HSP70.

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Available abstract

OBJECTIVE To study the expression of HSP70 in myocardial tissue in rats with endotoxemia and the effects of pentoxifylline.METHODS Set the models of rats with acute endotoxemia by the method of injecting LPS directly. Wistar rats were randomly divided into 3 groups,sham operated control ,LPS and PTX . The immunohistochemistry and western blotting were both used to assess the expression of HSP70 in the myocardial tissues.RESULTS The levels of HSP70 in the myocardial tissues in L group are higher than those in sham operated control group (P0.01) (immunohistochemistry and Western blotting). After PTX treatment, the levels of HSP70 in the myocardial tissues in P group are higher than those in L group (P0.01) (immunohistochemistry and western blotting).CONCLUSION The expression of HSP70 in myocardial tissues elevated in rats with endotoxemia and PTX can eliminate the myocardial injury and protect the myocardial tissues by further elevating the expression of HSP70.

Key concepts: Pentoxifylline, Hsp70, Immunohistochemistry, Blot, Medicine, Heat shock protein, Internal medicine, Shock (circulatory)

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