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2013•Chinese Journal of General PracticeRequires access

Relationship between VEGF-C and Lymphangiogenesis,Lymph Node Metastasis in Colon Carcinoma

Yin Tan

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Abstract

Objective To explore the relationship between VEGF-C and lymphangiogenesis,lymphatic metastasis in colon carcinoma.Methods Total 50 patients with colon carcinoma(Study Group) diagnosed by surgery and pathology were divided into lymph node metastasis subgroup(28 cases) and non-metastasis subgroup(22 cases).40 patients with benign colon polyp(Control Group) were collected.The expression of VEGF-C and VEGFR-3 in tumor tissues was detected by immunohistochemical technology.The relationship between VEGF-C expression and LVD,lymph node metastasis was analyzed.Results Study group had significantly higher VEGF-C positive rate and LVD level as compared to Control Group(P0.01).Lymph node metastasis subgroup had a higher VEGF-C expression as compared to non-metastasis subgroup(90% vs 31.8%,P0.01).Conclusion The high expression of VEGF-C may accelerate lymphatic metastasis in colon carcinoma by lymphangiogenesis.

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Objective To explore the relationship between VEGF-C and lymphangiogenesis,lymphatic metastasis in colon carcinoma.Methods Total 50 patients with colon carcinoma(Study Group) diagnosed by surgery and pathology were divided into lymph node metastasis subgroup(28 cases) and non-metastasis subgroup(22 cases).40 patients with benign colon polyp(Control Group) were collected.The expression of VEGF-C and VEGFR-3 in tumor tissues was detected by immunohistochemical technology.The relationship between VEGF-C expression and LVD,lymph node metastasis was analyzed.Results Study group had significantly higher VEGF-C positive rate and LVD level as compared to Control Group(P0.01).Lymph node metastasis subgroup had a higher VEGF-C expression as compared to non-metastasis subgroup(90% vs 31.8%,P0.01).Conclusion The high expression of VEGF-C may accelerate lymphatic metastasis in colon carcinoma by lymphangiogenesis.

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Available abstract

Objective To explore the relationship between VEGF-C and lymphangiogenesis,lymphatic metastasis in colon carcinoma.Methods Total 50 patients with colon carcinoma(Study Group) diagnosed by surgery and pathology were divided into lymph node metastasis subgroup(28 cases) and non-metastasis subgroup(22 cases).40 patients with benign colon polyp(Control Group) were collected.The expression of VEGF-C and VEGFR-3 in tumor tissues was detected by immunohistochemical technology.The relationship between VEGF-C expression and LVD,lymph node metastasis was analyzed.Results Study group had significantly higher VEGF-C positive rate and LVD level as compared to Control Group(P0.01).Lymph node metastasis subgroup had a higher VEGF-C expression as compared to non-metastasis subgroup(90% vs 31.8%,P0.01).Conclusion The high expression of VEGF-C may accelerate lymphatic metastasis in colon carcinoma by lymphangiogenesis.

Key concepts: Lymphangiogenesis, Medicine, Metastasis, Immunohistochemistry, Lymph node metastasis, Vascular endothelial growth factor C, Lymph, Lymphatic system

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