The levels of IL-6,IL-8 and IL-10 in serum and bronchoalveolar lavage fluid in patients with community-acquired pneumonia and its clinical significance

Objective: To explore the levels of IL-6,IL-8 and IL-10 in serum and bronchoalveolar lavage fluid( BALF) of patients with community-acquired pneumonia( CAP),and its clinical significance. Methods: The clinical pulmonary infection score of 50 patients with CAP were detected on the first day after admission. The patients with CPIS less than 6 and equal to or more than 6 were divided into the light group and severe group,respectively. Ten healthy people were set as the control group. The levels of IL-6,IL-8 and IL-10 in serum and BALF of the patients with CAP were determined by radioimmunoassay on the first day after admission. The levels of IL-6,IL-8 and IL-10 in serum of the patients with CAP were also measured on day 7 and 30 of admission. Results: The levels of IL-6,IL-8and IL-10 in serum and BALF of CAP patients were significantly higher than those in control group on the first day after admission( P 0. 05 to P 0. 01). The levels of IL-6 and IL-10 in serum and levels of IL-6,IL-8,IL-10 in BALF in severe CAP group were significantly higher in light CAP patients( P 0. 01). With the disease course prolonging,the levels of IL-6 and IL-10 decreased( P 0. 01),which arrived at the level of the control group on day 7 and 30 of admission( P 0. 05). The level of IL-8 in serum of CAP patients remained at a high level on day 30 of admission,which was significantly higher than that in control group( P 0. 01).Conclusions: The IL-6,IL-8 and IL-10 were involved in the pathogenesis of community-acquired pneumonia. The levels of IL-6 and IL-10 in serum and levels of IL-6,IL-8 and IL-10 in BALF can reflect the severity of pulmonary infection. The detection of IL-6,IL-8 and IL-10 in serum has certain clinical value in the early diagnosis of CAP.