GM-CSF gene-modified cancer vaccines for non-small cell lung cancer

Objective To construct the model of subcutaneously implanted Lewis lung cancer(LLC) on C57BL/6 mice and to explore the effect of GM-CFS tumor vaccine on the inhibition of Lewis lung cancer.Methods Fifty mice were randomly divided into five groups,group A(saline),group B(cisplatin),group C(YH-16),group D(DDP+YH-16),and group E(tumor vaccine).The life quality of the mice was observed,tumor growth curve was delineated,the body mass of mice and the mass of tumors were measured,and the tumor's suppress rate was calculated.Results By day 23 after treatment,tumor volume and mass were smaller in groups B,C,D and E than those in group A(P0.05).The tumor volume and mass were smaller in groups D and E than those in groups B and C(P0.05),and there was no significant difference between groups D and E(P0.05).The tumor inhibitory rate was 32.19%,55.08% and 54.30% in groups B,D and E,higher than that in group C(21.96%)(P0.05).There was no significant difference in mice body mass among groups A,C and E(P0.05).The mice body mass was larger in groups A,C and E than that in groups B and D(P0.05),was smaller in group B than that in group D(P0.05).Conclusion The inhibiting function of GM-CFS tumor vaccine is better than DDP,not inducing mice body mass loss,but GM-CFS tumor vaccine does not.