The Relationship between the TGFβ contain of Serum and Expression of Carcinoma in HRT Women with Cervix Cancer

Objective To explore the relationship between the contain of serum TGFβ and expression of carcinoma in HRT women with cervix cancer. Methods The level of serum TGFβ and expression of carcinoma were detected with enzyme-linked immunosorbent assay and immunohistinochemical staining respectively in 83 cases with cervix cancers and 40 normal control as well as 30 normal cervix issue. Results The contain of TGFβ in cervix cancer was higher than that in the normal. The contain of serum TGFβ in clinic stage Ⅱb~Ⅲ was higher than that inⅠ～Ⅱa, and contain of serum TGFβ with omentum metastasis than that without metastasis. There was not any significant relationship between expression of TGFβ and clinic-pathology. In different stages (before operation/radiotherapy, after operation/radiotherapy, in half and one year after operation/radiotherapy),the level of serum TGFβ was not significantly different in the patients with cervix cancers between the group HRT and NHRT, P 0.05 . There was not any significant relationship between TGFβ level of serum and expression of cancer. Conclusion TGFβ was almost similar in the patients with different TGFβ expression in cervix cancers issue. There was not significant relationship between HRT and TGFβ level of serum cervix cancer.