The expression and Biological significance of P27 in lung cancer progression tissue microarray

【Objective】To study the expressions of P27 in tissue microarray of lung cancer and its adjacent tissue and the relationships between its expressions and clinicopathological parameters in primary lung cancer.【Methods】We observed P27 protein expression in tissue microarray which contained 89 primary lung cancers,12 precancerous lesions,12 lung cancers with lymph node metastasis and 10 normal lung tissues using immunohistochemistry(IHC).【Results】The positive rate of P27 protein in normal lung tissue and precancerous lesion were significantly higher than that of primary lung cancer and lymph node metastasis of lung cancer(P0.05),In primary lung cancer,the expression of P27 protein was related to the degrees of differentiation and lymph node metastasis.It was higher in the group of high-middle differentiation than that of low-undifferentiation(P0.05),and the expression of P27 protein gradually decreased with increasing malignant degrees of lung cancer;it was higher in the group without lymph node metastasis than that with lymph node metastasis(P0.05);put there were no significant difference between the groups of different ages,sexes,histological types,gross types and clinical stages(P0.05).【Conclusions】Degree of expression of P27 protein is related with occurrence,progression,malignancy evaluation and metastasis.Lower expression of P27 protein plays an important part in the malignancy evaluation and unfavorable prognosis.