The expression and clinical significance of 14-3-3β protein in non-small cell lung cancer

Objective To investigate the expression and the clinical significance of 14-3-3β protein in NSCLC.Methods The expression of 14-3-3β protein in 85 cases of NSCLC were assessed by immunohistochemistry using tissue microarray technique,and the correlations with clinicopathologic findings and survival were statistically analyzed.Results The positive rate of 14-3-3β protein in NSCLC were 47%,and the positive rate in squamous carcinoma was significantly higher than in adenocarcinoma (57% vs 32%,P0.05);the median survival time were also significantly different in 14-3-3β protein positive and negative patients (56 months vs 42 months,P0.05).Conclusion 14-3-3β protein was expressed in NSCLC and more highly expressed in squamous carcinoma with a better prognosis.