Effects of ET-1 and CGRP Content on the Hemodialysis Blood Pressure in Patients with Renal Hypertension

Objective To investigate the effects of endothelin (ET-1) and calcitonin gene related peptide (CGRP) content before, during ad after hemodialysis (HD) on the blood pressure in patients with renal hypertension. Methods The subjective were divided into three groups: eighteen patients received HD with hypertension as hypertension group; thirteen patients received HD without hypertension as nonhypertension group, twenty healthy adults as control group. The blood pressure were taken and the levels of ET-1 and CGRP were measured by radioimmunoassy before, during and after HD. Results The ET-1 levels were significantly higher in patients received HD than that in normal controls (P 0. 05) and also significantly higher in patients with hypertension than that without hypertension (P 0. 05 ). The ET-1 levels in patients after HD were much lower than that before HD( (P 0. 01). There was a positive correlation between the levels of ET -1 and blood pressure (r3 =0. 607, r0=0. 587, P 0. 01) . The levels of CGRP were significantly lower in patients received HD than that in normal controls (P 0. 01).There was statistic difference in plasma CGRP levels between the HD with hypertension and without hypertension(P 0. 05) . There was a negative correlation between the levels of CGRP and blood pressure in patients with hypertension (r3 = -0.73, r0 = -0.69, P 0.01) . Nevertheless, there was no correlation between the levels of CGRP and blood pressure in patients without hypertension (r3 =0.19, r0 =0.16 , P 0. 05).