Preparation of arbidol hydrochloride sustained-release pellets and evaluation on the release behaviour

Objective To prepare arbidol hydrochloride sustained-release pellets and investigate the mechanism of release.Methods The orthogonal design was used to optimize the formulation of the core of pellets.Single-factor method was used to investigate the influence of contenting of plasticizer,anti-adherent,poremaking agent,coating levels on the release of the pellets.Results The core of pellets were prepared by MCC and lactose,with Eudragit RL30D as coating materials.The gained weight of the coated pellets was 20%.Conclusions The coated pellets has a remarkable sustained-release property,the drug release profile in vitro follows first order kinetics.