Relationship between maternal plasma procalcitonin and premature rupture of membranes

Objective To investigate the relationship between maternal plasma procalcitonin(PCT)and premature rupture of membranes(PROM)by detecting the concentration of PCT in pregnant women,and to explore the significance of PCT in the diagnosis of chorioamnionitis in pregnant wome with PPROM.Methods The serum PCT concentrations were measured in 55 pregnant women with PPROM and 40 healthy pregnant women at same pregnant term.40 pregnant women with PROM at term and 40 healthy pregnant women at same pregnant term,and Hematoxylin Eosin(HE)staining of placenta were performed after delivery of PPROM and PROM at term cases to observe the pathological changes of membranes of placenta.Results The positive rates of PCT in pregnant women with PPROM and PROM at term were significantly higher than those in control group(P0.05),however,there was no significant difference in the positive rates of PCT between pregnant women with PPROM and pregnant women with PROM(P0.05).Furthermore there was no significant difference in the positive rates of PCT between PPROM group with chorioamnionitis and PROM group without chorioamnionitis(P0.05).The sensitivity and specificity in pregnant women with PPROM identified according to PCT concentration were 60.00%,35.00%(PCT0.5μg/L);37.00%,60.00%(PCT2μg/L).Conclusion The PCT concentration in pregnant women with PPROM or PROM at term is increased,but its diagnostic value for chorioamnionitis in patients with PPROM needs to be researched further.