Clinical observation of different intensive insulin therapy in the treatment of type 2 diabetes mellitus T2DM

Objective To discuss the clinical effects of different intensive insulin therapy in the treatment of type 2 diabetes mellitus(T2DM). Method 126 patients with T2 DM were randomly divided into group A, B and C. Group A patients were treated with intensive therapy of insulin aspart with insulin pump, group B patients were treated with insulin aspart + bedtime insulin glargine subcutaneous injection therapy daily, group C patients were treated with insulin aspart 30 subcutaneous injection daily before meals, FPG, 2h PG, Hb A1 c and HOMA-IR were contrasted among the three groups before and after treatment, and standard time of blood glucose, insulin dosage of maintain blood glucose and incidence of hypoglycemia were contrasted among the three groups. Result There were no significant differences in FPG and 2h PG among the three groups before treatment(P 0.05), levels of FPG and Hb A1 c after treatment were significantly lower than before treatment, and the levels of FPG and 2h PG in group A were lower than group B and group C(P 0.05). There was no significant difference of Hb A1 c and HOMA-IR among the three groups before treatment(P 0.05), but after treatment, the above indexes were sighificantly lower than before treatment among the three groups(P 0.05), there were no significant differences after treatment among the three groups(P 0.05). There were significant differences in standard time of the blood glucose and insulin dosage among the three groups(P 0.05). There was no significant difference in incidence of hypoglycemia among the three groups(χ2 = 0.392, P = 0.072). Conclusion Insulin pump intensive therapy with aspart insulin dose and basal dose and pre-meal dose 1 ︰ 1 can more quickly control the blood glucose level to the target value, and can reduce the dosage of insulin in the treatment of patients with T2 DM, worthy of promotion.