The effect of increased endometrial thickness on the outcome of in vitro fertilization and embryo transfer

Objective To evaluate the relationship between increased endometrial thickness and the outcome of in vitro fertilization and embryo transfer(IVF-ET).Methods 314 IVF-EF in 265 patients were retrospectively analyzed.Endometrial thickness was measured by means of transvaginal ultrasound on the day of hCG administration.Patients were divided into two groups based on endometrial thickness.Group normal consisted of 233 cycles with endometrial thickness 7～14mm,and group thick included 32 cycles with endometrial thickness 14mm.Results Group thick cycles had significantly lower implantation and pregnancy rates compared with group normal cycles(9.1% versus 13.5% and 18.8% versus 27.0%,respectively).Group thick cycles had significantly higher miscarriage rates compared with group normal cycles(50.0% versus 19.0%,respectively).Conclusion Increased endometrial thickness is associated with the decreased implantation or pregnancy rates and the increased miscarriage rates in IVF-ET.