Ulinastatin for Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Objective To observe the therapeutic effect of ulinastatin in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Fifty-two patients with AECOPD were randomly divided into control group and ulinastatin group,with 26 patients in each group.All patients were given routine therapy with anti-infection,expectorant,sputum sucking,airway humidification,bronchodilators,corticosteroids,mechanical ventilation,maintaining acid-base balance and nutritional support.Patients in ulinastatin group were additionally treated with intravenous infusion of 200 000 U of AFT in 100 mL of normal saline 3 times per day.All patients received a 1-week course of treatment.Inflammation indicators and blood gases were measured before and after treatment.Results No significant differences in body temperature,white blood cell count,lactate levels,respiratory rate and arterial oxygen and carbon dioxide partial pressure were observed before treatment between control group and ulinastatin group(P0.05).At 1 week after treatment,white blood cell count,lactate levels,respiratory rate and arterial carbon dioxide partial pressure in ulinastatin group were lower than those in control group,but arterial oxygen partial pressure in ulinastatin group was higher than that in control group(P0.05).In addition,the total effective rate in ulinastatin group was higher than that in control group(92.3% vs 69.2%,P0.01).Conclusion Routine therapy combined with ulinastati can improve illness condition and prognosis in patients with AECOPD.