Significance of Serum Interleukin- 23 and Interleukin-17 on Patients with Sepsis

Objective To explore the clinical significance of serum interleukin-23( IL-23) and interleukin- 17( IL-17) on patients with sepsis. Methods 50 patients with sepsis admitted to our hospital from January 2012 to June 2013 were selected as sepsis group,according to the living condition of the 28 days of hospitalization patients were divided into subgroups survival( 29 cases) and death( 21 cases),50 cases of healthy people were selected as control group at the same period. The serum IL- 23 and IL- 17 were detected by ELISA. The APACHE Ⅱ score were evaluated in sepsis patients within 24 h after entering ICU. Results Serum IL- 23 and IL- 17 in sepsis group were higher than those of control group( P 0. 01). The APACHE Ⅱ scores and serum IL- 23 and IL- 17 in death subgroup were higher that those of survival group( P 0. 05). Serum IL- 23 and IL- 17 in sepsis patients were positively correlated with APACHE Ⅱ scores( r = 0. 73,0. 76). Conclusion Serum IL- 23 and IL- 17 in sepsis patients are closely related to the degree of critical illness,and also can be used as markers to reflect the changes.