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2011•Journal of Jilin Medical CollegeRequires access

The effect of TRAIL and cisplatin on inducing poptosis of Hela cells

Qi Ling

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Abstract

Objective To observe the effects of different dose of TRAIL and cisplatin on Hela cells.Methods Different concentration of TRAIL,TRAIL 100 ng/mL and cisplatin 10 μmol/L,combined TRAIL 100 ng/mL and cisplatin 10 μmol/L was treated on Hela cells for 24 hours respectively,the death rate of Hela cells was measured by ELISA.Results After being treated with different concentration TRAIL,Hela cells had death rates 10.91%,16.84%,22.79%,28.62%,34.85%;but after being treated with TRAIL,cisplatin,combined TRAIL and cisplatin,the Hela cells had death rates 28.07%,46.13%,75.51%.Conclusion TRAIL had obvious dose-effect on Hela cells and could increase the sensitivity of cells to drugs when combined with cisplatin.

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Objective To observe the effects of different dose of TRAIL and cisplatin on Hela cells.Methods Different concentration of TRAIL,TRAIL 100 ng/mL and cisplatin 10 μmol/L,combined TRAIL 100 ng/mL and cisplatin 10 μmol/L was treated on Hela cells for 24 hours respectively,the death rate of Hela cells was measured by ELISA.Results After being treated with different concentration TRAIL,Hela cells had death rates 10.91%,16.84%,22.79%,28.62%,34.85%;but after being treated with TRAIL,cisplatin,combined TRAIL and cisplatin,the Hela cells had death rates 28.07%,46.13%,75.51%.Conclusion TRAIL had obvious dose-effect on Hela cells and could increase the sensitivity of cells to drugs when combined with cisplatin.

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Available abstract

Objective To observe the effects of different dose of TRAIL and cisplatin on Hela cells.Methods Different concentration of TRAIL,TRAIL 100 ng/mL and cisplatin 10 μmol/L,combined TRAIL 100 ng/mL and cisplatin 10 μmol/L was treated on Hela cells for 24 hours respectively,the death rate of Hela cells was measured by ELISA.Results After being treated with different concentration TRAIL,Hela cells had death rates 10.91%,16.84%,22.79%,28.62%,34.85%;but after being treated with TRAIL,cisplatin,combined TRAIL and cisplatin,the Hela cells had death rates 28.07%,46.13%,75.51%.Conclusion TRAIL had obvious dose-effect on Hela cells and could increase the sensitivity of cells to drugs when combined with cisplatin.

Key concepts: HeLa, Cisplatin, Chemistry, Molecular biology, Cancer research, In vitro, Medicine, Biology

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