Observation the curative effect of ondansetron combined with metoclopramide on postoperative nausea and vomiting during patient controlled analgesia

Objective To observe the effect of ondansetron combined with metoclopramide on postoperative nausea and vomiting(PONV) during patient controlled analgesia.Methods 180 patients scheduled for hysterectomy under combined spinal-epidural anesthesia were randomly divided into three groups:group ondansetron(group Ⅰ),group metoclopramide(group Ⅱ),group ondansetron combined with metoclopramide(group Ⅲ).All patients received patient control epidural analgesia after operation and the drugs were infused into epidural space by PCA pump.Analgesia effect,sedation score,nausea and vomiting episodes were recorded for 24h after surgery.Results It had no significant difference among three groups at the VAS scores,sedation score and morphine dose.The incidence of nausea and vomiting in group Ⅲ(12% and 8%) was less than that in group Ⅰ(28% and 20%) and group Ⅱ(32% and 23%) evidently,and it had significant difference(P0.05).It had no significant difference between group Ⅰ and group Ⅱ(P0.05).Conclusion Ondansetron or metoclopramide gived alone can decrease the incidence of nausea and vomiting during PCEA.The combination of two antiemetics can reduce the incidence of nausea and vomiting further.