Relationship between polymorphisms of apolipoprotein E gene and serum lipids in Northern Chinese Han population

[Objective] To study the relationship between polymorphisms of apolipoprotein E(ApoE) gene and serum lipids in Northern Chinese Han population by gene level.[Methods] ApoE gene polymorphism was genotyped in 150 cardiovascular patients (patient group) and 130 healthy controls (control group) by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Meantime, the levels of serum lipids were measured. [Results]In comparison of the levels of serum lipids among three kinds of Apo E allele, the levels of TC, LDL-C and ApoB were decreased progressively according to e4 allele e3 allele e2 allele, which had a statistically difference (all P 0.05 in control group, all P 0.01 in patient group), while the levels of TG, HDL-C and ApoAI had no significant differentce among the three groups (all P 0.05). [Conclusions] ApoE gene polymorphism affects serum lipid metabolism in Northern Chinese Han population, and e4 allele has a function of increasing TC,LDL-C and ApoB.