Clinical analysis on 50 chronic kidney disease patients complicated with secondary hyperparathyroidism

Objective To investigate the changes of serum parathyroid hormone(PTH) and the disorders of phosphorus and calcium metabolism in chronic kidney disease(CKD) patients complicated with secondary hyperparathyroidism(SHPT) and the therapeutic regime. Methods Fifty CKD patients complicated with SHPT were randomly divided into two groups.Group B(20 cases) was treated by conventional method and group A(30 cases) was given additional calcitriol,phosphate binder and low calcium dialysis solutions.Serum PTH,alkaline phosphatase(ALP) and concentrations of calcium,phosphorus were detected and calcium-phosphorus product was calculated. ResultsCompared with group B and before treatment,the levels of serum PTH,ALP and calcium-phosphorus product were decreased during treatment period and the incidence of complications such as cardiovascular diseases,infection,renal osteopathy and anemia was lower in 20 weeks after treatment in group A(P0.05). Conclusion It is important to adjust the levels of serum phosphorus,calcium, PTH and ALP in CKD patients for reducing complications.