Changes of Blood Uric Acid and Its Significance in Patients with Liver Cirrhosis

Objective: To explore the changes and significance of blood uric acid (UA) level in patients with liver cirrhosis. Methods: 42 hospitalized patients who were diagnosed with liver cirrhosis were retrospectively analyzed (diseases and drugs which may affecting the UA metabolism were excluded). The changes of blood UA and the relationship between UA and its possible affecting factors such as age, sex, ascites, liver functional classification, serum creatinine(Cr) and blood direct bilirubin (D-BIL) were analyzed. 42 cases with matched age and sex were as the control. Results: There is no difference in age and sex in respect to the UA concentration. The total mean value of blood UA in patients with liver cirrhosis is 228.28± 136.83 μmol/L, which is significantly lower than that of control group(P 0.01);the mean value of D-BIL is 31.83± 46.01 μmol/L, which is significantly higher than that of control group(P 0.01).The mean value of serum creatinine (Cr)is 90.14± 83.43 mmol/L, which showed no significant difference(P 0.05) compare to the control group. Among 42 cirrhotic patients, the level of blood UA is normal in 28, high in 2 and low in 12 cases. There was significant difference in the value of UA between the normal UA group and the other 2 groups. But the D-BIL and Pugh-child classification in cases with decreased UA were significantly different from normal UA group(P 0.05 and 0.01). but there was no significant difference in ages, sex, creatinine level among the three groups. The level of UA in cases whose liver functional classification belong to C was lower than A group significantly(P 0.05). The value of UA in patients with ascites had no distinct difference from those without ascites. The results of multiple factor correlation analysis showed no correlation between blood UA and age, sex, ascites, liver functional classification, etiology, serum Cr and blood D-Bil. Conclusion: The level of UA in patients of Push-Child C was significantly lower than that of A group.It is suggested that UA negatively correlate with severity of hepatic cirrosis.