Plasma fatty acid analyses of essential hypertension

Objective:To explore the plasma fatty acid concentration in cases of essential hypertention(EH).Method:Plasma samples were collected from 56 patients with EH, 60 normal people as controls .Plasma total fatty acid concentration was analyzed with Morrison method and ran in 25-meter capillary gas-liquid chromatography.Result:Of the major fatty acid classes, (1) the percentage of C14:0, C16:0,C18:0 and total saturated were significanly higher in EH group than in control group, (2)The percentage of C18:1tr (trans oleic acid) was significantly higher in EH group than in control group. But the percentage of C18:1(oleic acid )was significantly lower in EH group than in control group. (3) Total polyunsaturated fatty acid,:① total n-3 and total n-6 polyunsaturated were lower in EH group than in control group .②the percentage of C18:2 n-6(Linoleic acid),C18:3 n-6(Υ-linic acid),C20:4 n-6(Arachidonic acid-AA),C22:4 n-6,C20:3 n-6;C20:5 n-6 in EH group were significantly lower than in control group;.③the percentage of C20:5 n-3(EPA) and C22:6 n-3(DHA) and C18:3 n-3 (a-linic acid). in EH group were significantly lower than in control group.Conclusion:Our datum demonstrated that the plasma fatty acid of EH was abnormal not only the percentage of C14:0, C16:0,C18:0, total saturated fatty acid and C18:1tr (trans oleic acid) were significantly higher than in control group, but also the percentage of C18:2 n-6(Linoleic acid) , C18:3 n-3(a-linic acid) ,C20:5 n-3(EPA) and C22:6 n-3(DHA) were significantly lower than in control, it is more important that we found the percentage of C18:3 n-6(Υ-linic acid ), C20:4 n-6(Arachidonic acid-AA) group,C20:3 n-6, C22:4 n-6 also significantly lower than that of control group.