2010•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access

The Research of Antitumor Effect of Artemisinin and its Derivatives in Vitro

Jingyan Wang

Abstract

Objective To observe the antitumor effect of artemisinin and its derivatives in vitro.Methods Microculture tetrazolium assay was applied to test the cytotoxicity of artemisinin,dihydroartemisinine,artemether and artesunate to human lung cancer A549 cell line,human gastric cancer BGC823 cell line,human colon carcinoma HCT116 cell line,human erythroleukemia K562 cell line and human hepatocarcinoma SMMC7721 cell line in vitro.Results Artemisinin,dihydroartemisinine,artemether and artesunate showed selective cytotoxicity to these five tumor cell lines.Conclusion Artemisinin,dihydroartemisinine,artemether and artesunate have different antitumor activities in vitro.

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Key concepts: Artemisinin, Artesunate, Artemether, Microculture, Cytotoxicity, In vitro, Artemisia annua, Cell culture