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The Expression and Significance of Interleukin-17(IL-17)、Bone Morphogenetic Protein-7(BMP-7) in the Herniated Lumbar Disc

Qiang Liu

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Abstract

Objective To investigate the expression of Interleukin-17(IL-17) and Bone Morphogenetic Protein-7(BMP-7) in normal and herniated discs,and analyze its role in hernimated discs.Methods The expression of IL-17 and BMP-7 was tested by immunohistochemistry method,thirty specimens of hemiated intervertebral disc tissue and ten normal disc tissue were immunostained with anti-human IL-17 and BMP-7 antibody.Results The results of average gray scale value of nucleus pulposus in control group were(112.077±4.353) and(103.605±4.696),respectively,(169.31±6.596) and(155.545±2.810) in experimental group.There was significant difference between the groups(P0.01).Conclusion IL-17 and BMP-7 are two important factors in intervertebral disc degeneration.IL-17 may be one of the important reasons leading to intervertebral disc degeneration.

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What this paper is about

Objective To investigate the expression of Interleukin-17(IL-17) and Bone Morphogenetic Protein-7(BMP-7) in normal and herniated discs,and analyze its role in hernimated discs.Methods The expression of IL-17 and BMP-7 was tested by immunohistochemistry method,thirty specimens of hemiated intervertebral disc tissue and ten normal disc tissue were immunostained with anti-human IL-17 and BMP-7 antibody.Results The results of average gray scale value of nucleus pulposus in control group were(112.077±4.353) and(103.605±4.696),respectively,(169.31±6.596) and(155.545±2.810) in experimental group.There was significant difference between the groups(P0.01).Conclusion IL-17 and BMP-7 are two important factors in intervertebral disc degeneration.IL-17 may be one of the important reasons leading to intervertebral disc degeneration.

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Available abstract

Objective To investigate the expression of Interleukin-17(IL-17) and Bone Morphogenetic Protein-7(BMP-7) in normal and herniated discs,and analyze its role in hernimated discs.Methods The expression of IL-17 and BMP-7 was tested by immunohistochemistry method,thirty specimens of hemiated intervertebral disc tissue and ten normal disc tissue were immunostained with anti-human IL-17 and BMP-7 antibody.Results The results of average gray scale value of nucleus pulposus in control group were(112.077±4.353) and(103.605±4.696),respectively,(169.31±6.596) and(155.545±2.810) in experimental group.There was significant difference between the groups(P0.01).Conclusion IL-17 and BMP-7 are two important factors in intervertebral disc degeneration.IL-17 may be one of the important reasons leading to intervertebral disc degeneration.

Key concepts: Medicine, Bone morphogenetic protein, Intervertebral disc, Immunohistochemistry, Bone morphogenetic protein 2, Bone morphogenetic protein 7, Pathology, Anatomy

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The Expression and Significance of Interleukin-17(IL-17)、Bone Morphogenetic Protein-7(BMP-7) in the Herniated Lumbar Disc — Research Paper | ScholarLens