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Expression of cyclooxygenase-2 in ovarian cancer

Wang Ze-hu

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Abstract

Objective To investigate the expression of cyclooxygena se -2(COX-2)in ovarian cancer. Methods RT-PCR and immunohistochemical method were used to investigate the expression of cyclooxygenase-2 in 38 patients wit h ovarian cancer. Results COX-2 protein expressions were detected in 23 of 38 ovarian cancers and the positive rate was 61% . COX-2 mRNA expressions were detected in 33 of 38 ovarian cancers and the positive rate was 87% . No COX-2 protein and mRNA expression was detecte d in 20 normal ovaries.Conclusion Increased expression of COX-2 protein and mR NA in human ovarian cancer, and it might be the important factor in development of ovarian cancer.

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What this paper is about

Objective To investigate the expression of cyclooxygena se -2(COX-2)in ovarian cancer. Methods RT-PCR and immunohistochemical method were used to investigate the expression of cyclooxygenase-2 in 38 patients wit h ovarian cancer. Results COX-2 protein expressions were detected in 23 of 38 ovarian cancers and the positive rate was 61% . COX-2 mRNA expressions were detected in 33 of 38 ovarian cancers and the positive rate was 87% . No COX-2 protein and mRNA expression was detecte d in 20 normal ovaries.Conclusion Increased expression of COX-2 protein and mR NA in human ovarian cancer, and it might be the important factor in development of ovarian cancer.

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Available abstract

Objective To investigate the expression of cyclooxygena se -2(COX-2)in ovarian cancer. Methods RT-PCR and immunohistochemical method were used to investigate the expression of cyclooxygenase-2 in 38 patients wit h ovarian cancer. Results COX-2 protein expressions were detected in 23 of 38 ovarian cancers and the positive rate was 61% . COX-2 mRNA expressions were detected in 33 of 38 ovarian cancers and the positive rate was 87% . No COX-2 protein and mRNA expression was detecte d in 20 normal ovaries.Conclusion Increased expression of COX-2 protein and mR NA in human ovarian cancer, and it might be the important factor in development of ovarian cancer.

Key concepts: Ovarian cancer, Immunohistochemistry, Cyclooxygenase, Messenger RNA, Protein expression, Medicine, Internal medicine, Cancer

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