Salvianolic Acid B Improves Glucose and Lipid Metabolism and Insulin Resistance in Rat Models with Type 2 Diabetes

Objective:To study the effects of salvianolic acid B(Sal-B) on blood glucose,lipid,renal function,insulin levels,as well as insulin and glucose tolerance in rat models with type 2 diabetes.Method:The rat type 2 diabetes model was established by feeding with high glucose and fat diets and intraperitoneally injecting with 30 mg·kg-1 STZ.The rats were divided into four groups: normal,model,diamicron(26.7 mg·kg-1)and Sal-B(187 mg·kg-1) group,corresponding drugs were orally administrated for four weeks.At the end of administration,blood samples were collected,and blood glucose,glycosylated hemoglobin(HBA),triglyceride,total cholesterol,creatinine,blood urea nitrogen,and insulin levels were detected.Then insulin sensitivity index was calculated.Insulin sensitivity of rats was evaluated by insulin and glucose tolerance tests.Result:Sal-B and diamicron not only significantly decreased fasting blood glucose and lipid,insulin and HbA1 c levels(P0.01),but also improved renal function,insulin sensitivity,insulin and glucose tolerance,which were remarkably different from the model group(P0.05,P0.01).Conclusion: Sal-B can lower blood glucose and lipid levels,protect kidney,ameliorate glucose and lipid disorders,and insulin resistance in rat models with type 2 diabetes.