ScholarLens Back to search
2000•TumoriRequires access

ALL TRANS RETINOIC ACID INDUCED DIFFERENTIATION AND APOPTOSIS OF COLORECTAL CANCER CELL LINE LoVo

A. Lu

Open publisher page 0 citations

Abstract

Objective The potential roles of all trans retinoic acid (ATRA) in colorectal cancer cell line LoVo in vitro were studied.Methods The proliferation, the cell cycle and the apoptosis of LoVo cells were determined after treated with ATRA.Results ATRA could significantly inhibit proliferation of LoVo and greatly increase ALP of the cells in time dependent manner.In cytometry analysis,LoVo cells lines accumulated in G 1 phase and appeared an extra “sub G 0/G 1 peak” when higher dosage of ATRA was presented.Apoptotic cells only in 10 -5 mol ATRA were found by electronic microscopy.Conclusion ATRA could both induce differentiation and apoptosis of LoVo cells.This observation may become an indicator for clinical trials on prevention of colorectal cancer.$$$$

About this research paper

What this paper is about

Objective The potential roles of all trans retinoic acid (ATRA) in colorectal cancer cell line LoVo in vitro were studied.Methods The proliferation, the cell cycle and the apoptosis of LoVo cells were determined after treated with ATRA.Results ATRA could significantly inhibit proliferation of LoVo and greatly increase ALP of the cells in time dependent manner.In cytometry analysis,LoVo cells lines accumulated in G 1 phase and appeared an extra “sub G 0/G 1 peak” when higher dosage of ATRA was presented.Apoptotic cells only in 10 -5 mol ATRA were found by electronic microscopy.Conclusion ATRA could both induce differentiation and apoptosis of LoVo cells.This observation may become an indicator for clinical trials on prevention of colorectal cancer.$$$$

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective The potential roles of all trans retinoic acid (ATRA) in colorectal cancer cell line LoVo in vitro were studied.Methods The proliferation, the cell cycle and the apoptosis of LoVo cells were determined after treated with ATRA.Results ATRA could significantly inhibit proliferation of LoVo and greatly increase ALP of the cells in time dependent manner.In cytometry analysis,LoVo cells lines accumulated in G 1 phase and appeared an extra “sub G 0/G 1 peak” when higher dosage of ATRA was presented.Apoptotic cells only in 10 -5 mol ATRA were found by electronic microscopy.Conclusion ATRA could both induce differentiation and apoptosis of LoVo cells.This observation may become an indicator for clinical trials on prevention of colorectal cancer.$$$$

Key concepts: Apoptosis, Retinoic acid, Colorectal cancer, Cell cycle, Cell culture, Cancer research, Cell growth, Flow cytometry

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
ALL TRANS RETINOIC ACID INDUCED DIFFERENTIATION AND APOPTOSIS OF COLORECTAL CANCER CELL LINE LoVo — Research Paper | ScholarLens