Influences of Salvia Miltiorrhiza Injection on clinical efficacy and CD4~+ CD25~+ Regulatory T Cells of asthmatic patients

Objective To investigate the influences of Salvia Miltiorrhiza Injection on clinical efficacy and CD4+ CD25+ Regulatory T Cells of asthmatic patients,and elucidate the possible mechanism of salvia miltiorrhiza injection in treatment of asthma.Methods 62 asthmatic patients were randomly divided into control group and salvia miltiorrhiza-treated group.The symptom scores,forced expiratory volume in one second(FEV1)and peak flow rate(PEF)were monitored.Flow cytometry was used to detect the CD4+ CD25+ Treg ratio in PBMCs.Results Compared with before treatment,symptom scores of two groups significantly decreased(P0.05).The decrease in therapy group was more significant than that in control group(P0.05).Compared with before treatment,FEV1,PEF and CD4+ CD25+ Treg ratio of two groups significantly increased(P0.05).The increase in therapy group was more significant than that in control group(P0.05).Conclision Salvia miltiorrhiza injection could treat asthmatic patients effectively,probably by increasing the number of CD4+ CD25+ Treg.