2005•Hebei yixueRequires access
Effect of Salvia Miltiorrhiza Injection on IL-6、IL-8 and TNF-α in the Patients with Type II Diabetic Nephropathy
Zhen Zhuo-li
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Abstract
Objective: To observe the effect of Salvia miltiorrhiza injection on IL-6、IL-8 and TNF-α in the patients with type Ⅱ diabetic nephropathy and to study the curing mechanism of Salvia miltiorrhiza injection to diabetic nephropathy. Methods: 32 patients with II type diabetic nephropathy were treated with Salvia miltiorrhiza injection, and 28 diabetic nephropathy patients remedied routinely were taken as contrasts. The levels of IL-6、IL-8 and TNF-α in the blood of patients were tested both before the treatment and after cure courses.Results: The total utility rate (71.8%) of Salvia miltiorrhiza injection to diabetic nephropathy was significantly higher than that of control group(43.8%). After the treatment, the levels of IL-6、IL-8 and TNF-α in the group treated with Salvia miltiorrhiza injection were lower than that of control group, and the 24h urine protein of Salvia miltiorrhiza injection treated group were significantly lower than that of control group. The 24h urine protein in Salvia miltiorrhiza injection treated group were positively correlated to IL-6、IL-8 and TNF-α. Conclusion: There was a significant treatment effect of Salvia miltiorrhiza injection on the patient with type Ⅱ diabetic nephropathy. The curing mechanism of Salvia miltiorrhiza injection to diabetic nephropathy may be this traditional Chinese medicine can regulate the production of inflammatory cytokins and can inhibit inflammatory reaction.