Protective Effect of Sodium Ferulate on Liver Ischemia/Reperfusion Injury in Rats with Cirrhosis

Objective To study the preventive effect of the damage of ischemia-reperfusion(I/R) in rat liver with cirrhosis by applying sodiuim ferulate (SF) Methods The model of liver cirrhosis was established by subcutaneous injection of carbon tetrachloride(CCL4) in rats.Then 30 rats of liver cirrhosis were randomized into 3 groups.In group A(n=10),sham operation was performed.In control group B and protection group C with 10 rats in each,were injected NS 1.5 ml or SF 1.5 ml(150 mg/kg) by tail vein,respectively,then hepatic warm ischemia was achieved for 30 min.The liver function parameters superoxide dismutase(SOD),malonyldialdehyde(MDA),nitric oxide(NO) in liver tissues,and the liver histologic changes after 2 hours of reperfusion in both groups were compared.Results After 2 hours of reperfusion,compared with controlled group,the serum AST,ALT,LDH and MDA contents significantly decreased(P0.01);the liver contents of SOD and NO significantly increased(P0.01) in SF protection group;light and electron microscopy showed that in SF protection group the degree of liver injury was much less than in control group. Conclusion SF plays a protective effect on I/R injury of cirrhotic liver in rats.