Clinical Significance of Detection of S - 100β Protein in Cerebrospinal Fluid and Serum of Children with Acute Viral Encephalitis

Objective To explore the changes of S - 100β protein in cerebrospinal fluid and serum of children with viral encephalitis and its clinical significance. Methods The levels of S - 100β protein of cerebrospinal fluid and serum of 36 children with viral encephalitis and 20 lumbar anesthesia children without central nervous system diseases were measured by enzyme - linked immunosor bent assay. Differences in the levels of cerebrospinal fluid and serum S-100β protein between children with and without coma, with and without convulsion, with and without sequelae in the case group were compared. Results S-100β protein levels of cerebrospinal fluid in the case group and control group were (0.641±0.390) and (0.037 ± 0.014) μg/L( P 0.01). Serum S - 100β protein levels in the case group and control group were (0.444±0.257 ) and (0.023±0.009)μg/L(P0.05).The cerebrospinal fluid and serum S- 100β protein levels of children with coma were significantly higher than those of children without coma(all P0.01) ,and those of children with convulsion were higher than those of children without convulsion(all P0.01). The cerebrospinal fluid and serum S-100β protein levels of children with sequelae were significantly higher than those of children without sequelae(all P 0. 01). Conclusions The cerebrospinal fluid and serum S - 100β protein levels of children with viral encephalitis relates to degree of severity. Detection of S - 100β protein of children with viral encephalitis contributes not only to assess the severe degree but also to predict their prognoses.