Analysis on drug resistance of Escherichia coli resistant to Levofloxacin

Objective To investigate the isolated rate of Escherichia coli among Zigong First Peoples’ Hospital and analyze the drug resistance of strains resistant to Levofloxacin.Methods Kirby-Bauer’s detection technique was applied to detect the resistance feature in 154 strains of Escherichia coli collected from August 2009 to August 2010.Results Total of 76 strains resisted to Levofloxacin were detected in 154 strains of Escherichia coli,with the detection rate as 49.35%.Among the specimens,the isolated rate of strains resistant to Levofloxacin in urina was the highest (51.32%) and the second was in sputum (23.68%).Except for imipenem,mlopenem,cefoxitin,piperacillin/tazobatan and amikacin,the resistance rate of Levofloxacin-resistant strains were significantly higher than that of non-Levofloxacin-resistant strains to ampicillin,cefazolin,cefepime,cefotaxime,ceftazidime,gentamycin,cefoperazone/sulbactam(P 0.05).Conclusions Levofloxacin-resistant Escherichia coli is resistant to many antibacterial agents.Monitoring of Levofloxacin-resistant strains should be strengthened and the indication of antibiotics must be mastered strictly to prevent the dissemination of drug resistant strains.