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2005•Immunological JournalRequires access

Progress in mechanisms of RNAi and its functions

Yuan Yang, Meng Wang

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Abstract

RNA interference (RNAi) is a post-transcriptional gene silencing induced by introduction of double-stranded RNA (dsRNA). RNAi can down-regulate gene expression in cell, which not only be a powerful tool in gene functional research, but also provides a new technique for gene therapy. This review introduces the enzymes, proteins, triggers, and regulators associated with mechanisms of RNAi, as well as the applications of RNAi in biology.

About this research paper

What this paper is about

RNA interference (RNAi) is a post-transcriptional gene silencing induced by introduction of double-stranded RNA (dsRNA). RNAi can down-regulate gene expression in cell, which not only be a powerful tool in gene functional research, but also provides a new technique for gene therapy. This review introduces the enzymes, proteins, triggers, and regulators associated with mechanisms of RNAi, as well as the applications of RNAi in biology.

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Method / approach

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Available abstract

RNA interference (RNAi) is a post-transcriptional gene silencing induced by introduction of double-stranded RNA (dsRNA). RNAi can down-regulate gene expression in cell, which not only be a powerful tool in gene functional research, but also provides a new technique for gene therapy. This review introduces the enzymes, proteins, triggers, and regulators associated with mechanisms of RNAi, as well as the applications of RNAi in biology.

Key concepts: RNA interference, RNA silencing, Gene silencing, Biology, Gene, Gene expression, Cell biology, Computational biology

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