2005•The Journal of Cervicodynia and LumbodyniaRequires access
Neuroprotective effect of high-dose methylprednisolone in prophylaxis in rat acute spinal cord injury
LI Jia-shun
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Abstract
Objective To study the neuroprotective effect of high-dose methylprednisolone in prophylaxis in rat acute spinal cord injury. Methods The rats were randomly divided into three groups:Control groups,acute spinal cord injury groups,administration of methylprednisolone in prophylaxis. Allen's weight drop model of acute spinal cord injury was prepared and to study the ratio of Tarlov's motor scales,ratio of Molt's inclined plane scales,pathological and ultrastructural changes of spinal cord,neurofilament and glial fibrillary acidic protein at 24- and 72-hour after ASCI,respectively. Results The pathological and ultrastructural changes of spinal cord were significantly improved in MP groups. The neurological function of rats in MP groups was significantly improved at 72-hour after ASCI. The expression of NF significantly increased and the expression of GFAP significantly decreased in MP groups. Conclusion There is neuroprotective effect of high-dose methylprednisolone in prophylaxis in rat acute spinal cord injury.