Bacteria Producing Extended-spectrum Beta-lactmases in Respiration System:the Clinical Investigation

OBJECTIVE To study the production of Gram-negative bacilli extended-spectrum beta-lactmases in respiratory system nosocomial infection, detect bacterial resistance and direct the appropriate use of antibiotics in clinic. METHODS The survey is based on the analysis of a number of collected nosocomial infection cases related to ESBL-producing Gram-negative bacilli from Jan 2001 to Aug 2002. Bacterial culture was performed with routine method: drug susceptibility test Api was used according NCCLs. RESULTS In this sample, productive rate of ESBLs was 20 7%. The bacteria producing ESBLs were mainly from Escherichia coli, Klebsiella pneumoniae and other bacteria. These bacteria were all resistant to cefoxitin, aminoglycosides, sulfanilamides, quinolones, but susceptible to imipenem. ICU is a high-dangerous area, the elderly is a susceptive group. CONCLUSIONS Detection of ESBLs is good to direct appropriate use of antibiotics. It is a necessary method to prevent the outbreak of ESBLs.