Peripheral CD4~+CD25~+Foxp3~+ Regulatory T cells in Patients with NSCLC and Its Clinical Significance

[Purpose] To investigate the expression of CD4+CD25+Foxp3+ regulatory T cells(Treg)in peripheral blood in patients with NSCLC and its significance.[Methods] The proportion of CD4+CD25+Foxp3+ Treg in thirty cases with NSCLC and 12 healthy controls were measured by flow cytometry.[Results] The proportion of CD4+CD25+Foxp3+ Treg in peripheral blood from patients with NSCLC(6.24%±2.01%) was higher than that from healthy controls(4.83%±0.85%)(P0.05).The proportion of peripheral CD4+CD25+Foxp3+ Treg in patients with NSCLC was not different with agender,age,pathology,KPS score and tumor marker level(P0.05).The proportion of CD4+CD25+Foxp3+ Treg in the patients with NSCLC stage Ⅳ was higher than that in stage Ⅰ～Ⅲ(P0.05).The proportion of CD4+CD25+Foxp3+ Treg in the patients bearing tumor was higher than those without tumor(P0.05).The proportion of CD4+CD25+Foxp3+ Treg in patients with Qi deficiency syndrome or blood stasis syndrome was higher than those without the syndromes(P0.05).[Conclusion] Detecting the expression of CD4+CD25+Foxp3+ Treg in peripheral blood of patients with NSCLC is helpful for knowing cancer progression and the patients immunity.The increase of the proportion of CD4+CD25+Foxp3+ Treg closely correlates to Qi deficiency syndrome and blood stasis syndrome.