Therapeutic Effect of TCM Syndrome Differentiation and Treatment for IgA Nephropathy

【Objective】To explore the therapeutic effect of TCM syndrome differentiation and treatment for immunoglobulin A(IgA) nephropathy.【Methods】The selected 123 patients with IgA nephropathy were divided into two groups(in the proportion of 3∶1) by number randomization.Group A(n=86) was given Tripterygium Glycosides tablets and differential treatment according to syndrome patterns,and Group B(n=37) was given routine western medicine including anti-inflammation drugs,drugs for controlling blood pressure and glucocorticoid hormone.The two groups received a 3-month treatment course and received one more course according to individual cases.The total therapeutic effect,effect for TCM syndrome patterns,and toxic and side effects were observed.The changes of TCM syndrome scoring were compared before and after treatment.【Results】In group A,symptoms were completely relieved in 29,markedly relieved in 30,relieved in 15 and un-relieved in 12 patients,the total effective rate being 86.05%,while respectively in 4,5,10 and 18 of patients in group B,the total effective rate being 51.35%.The total effect was better in group A than that in group B(P0.01).For yin deficiency,TCM syndrome-differentiation treatment was more effective than routine western treatment(P0.01),but for yang deficiency and deficiency of both yin and yang,the former is similar to the latter(P0.05).The improvement on TCM syndrome scoring in group A was superior to that in group B(P0.01).No toxic effect was found in the two groups during the treatment.【Conclusion】TCM syndrome differentiation and treatment is effective for IgA nephropathy,especially for IgA nephropathy with yin deficiency,and is safe with less toxic and side effects.