Expression of β-catenin and P65 in laryngeal carcinoma and its biological significance

Objective To study the expression of β-catenin(β-cat) and P65 in laryngeal carcinoma and its correlation with pathological classification and clinical stages.Methods S-P immunochemical method was performed to detect the expression of β-cat and P65 in 42 specimens of laryngeal carcinoma and 20 of para-carcinoma tissue.The correlation between expression and pathological classification and clinical stages was analyzed.Results ① The abnormal expression rates of β-cat and P65 in laryngeal carcinoma tissue were66.7% and71.4% respectively.The differences of expression rates between laryngeal carcinoma and para-carcinoma tissue were statistically significant(P0.01).② Abnormal expression of β-cat was closely related with pathological differentiation,clinical stages,lymph node metastasis and 5-year survival rate;its abnormal expression rate increased with the rise of pathological classification and clinical stages(P0.05).Abnormal expression of P65 was closely related with clinical stages,lymph node metastasis(P0.05),but not with pathological classification and 5-year survival rate(P0.05).③ P65 and β-cat were simultaneously expressed in 22 specimens of laryngeal carcinoma and the expression of P65 was significantly correlated with that of β-cat(r=0.392,P0.05).Conclusion The expression of P65 is closely correlated with that of β-cat in laryngeal carcinoma.The abnormal expression of P65 and β-cat is closely related with differentiation,clinical stage,metastases in this tumor.