2010•Zhongguo yaofangRequires access
Comparison of Antihypertensive Effect of Irbesartan and Amlodipine and Effect of Them on Serum Free Fat Acid
Liu Qiang, Qiang She
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Abstract
OBJECTIVE: To investigate clinical efficacy of irbesartan and amlodipine on primary hypertension and the influence of them on serum free fatty acid.METHODS: 120 cases diagnosed primary hypertension were randomly divided into 2 groups.Observation group was treated with irbesartan 150 mg once a day and control group was treated with amlodipine 5 mg once a day.The changes of blood pressure and free fatty acid were observed after 4 weeks and 8 weeks of treatment.RESULTS: The effective rates of 2 groups were 83.3% and 66.7% after 4 weeks.There were significant difference between 2 groups(P0.05).After 8 weeks the effective rates of 2 groups had no significant difference(P0.05).Compared with control group,the level of free fatty acid in serum was reduced significantly in observation group(P0.05).CONCLUSION: Compared with amlodipine,irbesartan not only has obvious effect on lowering blood pressure,but can also reduce the level of free fatty acid in serum.Irbesartan is an ideal choice for hypertensive patients.