Relation of the variations of S100Bprotein levels and brain damage in neonatal asphyxia

Objective To study the changes of S100Bprotein levels and the relation of brain damage to their in neonatal asphyxia.Methods The concentrations of IL-6 and IGF-1 in peripheral serum were detected in 50 asphyxiated newborn and 20 normal newborns(control group) by the method of ELISA,And analyse the relation of brain damage to their in neonatal asphyxia.Results The concentration of S100Bprotein in asphyxiated newborn was higher than that of normal newborns in acute phase.The S100Bprotein in the patients with brain damage displayed by skull-CT were higher than those in the patients without brain damage(P0.05).The level of S100B protein in recovery phase was significantly lower than that in acute phase(P0.01).Conclusion the concentration of S100Bprotein in peripheral blood of asphyxiated newborn increase significantly.It might be a valuable index for the diagnosis of neonatal asphyxia following brain damage.