Expression of p57~(kip2) and Cyclin E Protein in Human Glioma and its Clinical Significances

Objective To explore the expression of p57 kip2、Cyclin E in human gliomas and its clinical significances. Methods The expression of p57 kip2 and Cyclin E proteins in human glioma tissues in 46 patients was detected by SP immunohistochemical technique. Results The p57 kip2protein positive-expression rate in human glioma was 34.8%, which was lower than that in normal brain tissue (P 0.05). The p57 kip2 protein positive-expression correlated significantly with clinicopathologic grade (P 0.05)and the two-year survival time (P 0.01) . The Cyclin E positive-expression rate in human glioma was 58.6%.The Cyclin E positive-expression also correlated significantly with clinicopathologic grade (P 0.05) and the two-year survival time (P 0.05).There were significant correlation with the expression of p57 kip2 protein and Cyclin E protein (r s = -0.359, P 0.05). Conclusion The expression of p57 kip2 protein and Cyclin E protein plays an important role in the development of glioma .They also correlated significantly with the differentiation degree of human gliomas and Prognosis.