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2012•Journal of Hunan UniversityRequires access

Study on Synthesis and Anticancer Activities of New Norlignans Derivatives

Zhiwu Liang

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Abstract

In this study,we have synthesized a series of new norlignan compounds 2a-2g and evaluated their anticancer activities with MTT assay by using human hepaioma Bel-7402 cells,human breast adenocarcinoma MCF-7 cells,human lung carcinoma A549 cells and human cervical carcinoma HeLa cells.It has been shown that the products(2a-2g) exhibit higher cytotoxicity to cells,and especially,product 2b treated with Bel-7402 cells shows a lower cytotoxicity(IC50: 18.9 μg/mL) than free paclitaxel.

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What this paper is about

In this study,we have synthesized a series of new norlignan compounds 2a-2g and evaluated their anticancer activities with MTT assay by using human hepaioma Bel-7402 cells,human breast adenocarcinoma MCF-7 cells,human lung carcinoma A549 cells and human cervical carcinoma HeLa cells.It has been shown that the products(2a-2g) exhibit higher cytotoxicity to cells,and especially,product 2b treated with Bel-7402 cells shows a lower cytotoxicity(IC50: 18.9 μg/mL) than free paclitaxel.

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Available abstract

In this study,we have synthesized a series of new norlignan compounds 2a-2g and evaluated their anticancer activities with MTT assay by using human hepaioma Bel-7402 cells,human breast adenocarcinoma MCF-7 cells,human lung carcinoma A549 cells and human cervical carcinoma HeLa cells.It has been shown that the products(2a-2g) exhibit higher cytotoxicity to cells,and especially,product 2b treated with Bel-7402 cells shows a lower cytotoxicity(IC50: 18.9 μg/mL) than free paclitaxel.

Key concepts: Cytotoxicity, HeLa, MTT assay, Human lung, Cervical carcinoma, Paclitaxel, Chemistry, Human breast

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