2020•RSC AdvancesOpen access

Synthesis and biological evaluation of dehydroabietic acid-pyrimidine hybrids as antitumor agents

Lin Huang, Rong Huang, Fuhua Pang, Anke Li, Guobao Huang, Xiaoqun Zhou, Qian Li, Fangyao Li, Xian‐Li Ma

Abstract

values ranging from 7.00 to 11.93 μM against all the tested cell lines and displayed weak cytotoxicity towards normal cells. Besides, cell cycle analysis indicated that compound 3b mainly arrested MCF-7 cells at the S stage and induced cell apoptosis.

Open-access reader

About this research paper

What this paper is about

Why it matters

OpenAlex reports 19 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Pyrimidine, Hybrid, Chemistry, Combinatorial chemistry, Stereochemistry, Pharmacology, Biology, Botany